Unlimited viewing of the articlechapter pdf and any associated supplements and figures. Get a printable copy pdf file of the complete article. There is a newer version of this article kelly a skinner. Increased dietary fructose linked to elevated uric acid levels and lower liver energy stores. Uric acid is the metabolic end product of purine metabolism in humans. Uric acid ua is the end product of purine metabolism and can reportedly act as an antioxidant. We describe different case scenarios of 4 sri lankan patients related to abnormal uric acid levels in blood and urine. Pdf uric acid as a modulator of glucose and lipid metabolism. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Increased dietary fructose linked to elevated uric acid. Get a printable copy pdf file of the complete article 1. In humans the final compound of purines catabolism is uric acid. Uric acid is, therefore, cleared from the plasma both by glomerular filtration and by tubular secretion.
First, uric acid is an antioxidant and can react with a variety of substances, resulting in the formation of allantoin from superoxide, triuret from reaction with peroxynitrite, or 6aminouracil from reaction with nitric oxide. Uric acid ua is the end product of the metabolic pathway for purines, the main constituents of nucleotides. Uric acid as a modulator of glucose and lipid metabolism. Effects on uric acid metabolism of the drugs except the. Links to pubmed are also available for selected references. University of alabama at birmingham, birmingham, alabama, usa. Studies on lactic acid metabolism in pregnancy and labor. Pdf regulation of uric acid metabolism and excretion. Uric acid is a strong reactive oxygen species ros and peroxynitrite scavenger and antioxidant. Pdf purines perform many important functions in the cell, being the formation of the monomeric precursors of nucleic acids dna and rna the. Role of uric acid metabolismrelated inflammation in the. Pdf the uric acid metabolism pathway as a therapeutic target in.
Uric acid ua increase is considered an important risk factor for the development of cardiovascular disease cvd favoring. Regulation of uric acid metabolism and excretion sciencedirect. Uric acid, an important screening tool to detect inborn. Most disorders of purine metabolism are expressed by a considerable variation in serum urate concentration and urinary uric acid excretion, since uric acid is the final product of purine metabolism in human beings see fig. The exogenous pool varies significantly with diet, and animal proteins. To understand the effects of those pharmacological agents on uric acid metabolism will help to avoid unexpected side effect of hyperuricemia and. Altered serum and urine uric acid level both above and below the reference ranges is an indispensable marker in detecting rare inborn errors of metabolism. High levels of uric acid are readily detected in the cytosol of normal human and mammalian cells, especially in the liver, vascular endothelial cells, and in human nasal secretions, where it serves as an antioxidant. Uric acid production and metabolism are complex processes involving various factors that regulate hepatic production, as well as renal and gut excretion of this compound. Variations of uric acid excretion with different types of food. The procedure has been to inject intravenously a single dose of isotopic uric acid, as its lithium salt, into normal and gouty human subjects maintained in nitrogen. Uric acid is a heterocyclic compoond o carbon, nitrogen, oxygen, an hydrogen wi the formula c 5 h 4 n 4 o 3. Uric acid metabolism in humans seminars in nephrology. Interrelation of uric acid and ethanol metabolism in man charles s.
Pdf in humans, uric acid is the final oxidation product of purine catabolism. The urinary excretion of uric acid is increased by the hormones of the adrenal cortex as well as by acth. Get a printable copy pdf file of the complete article 798k. Uric acid is the end product of an exogenous pool of purines and endogenous purine metabolism. A detailed clinical study from a given patient may disclose whether he or she has a congenital or an acquired disease. All other mammals possess the enzyme uricase that converts uric acid to. Physiological functions and pathogenic potential of uric.
Purine metabolism an overview sciencedirect topics. Full text full text is available as a scanned copy of the original print version. However, recently, numerous clinical and basic research. Uric acid metabolism skinner major reference works.